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Clinical trials that are designed to help inform practice in the real world are referred to as pragmatic trials. They are often characterized by their focus on practical aspects of designing a study which include the recruitment and consent process, as well as adherence and the use of routinely available equipment.
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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from various geographical areas. This type of heterogeneity is essential for pragmatic trials to be valid and also reduces bias in the results. However excessive heterogeneity could lead to problems with the design of the trial.
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Pragmatic trials are designed to replicate real-life settings and achieve maximum external validity. They are typically commissioned by policy makers and practitioners to guide their decision-making. They can be used to determine the cause-effect relationship of an intervention with its outcomes. However, they shouldn't be used in lieu for the use of explanation trials.
The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which validate the validity of a clinical or physiological hypothesis and pragmatic trials, which inform the policy and practice of. They also proposed an approach to pragmatic trials, called PRECIS.2 This tool was designed to define the characteristics of a pragmatic study, including the recruitment process, the design and delivery of the intervention, as well as follow-up.
There is an encouraging trend in the number of pragmatic trials that have been published. 프라그마틱 카지노 using the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs), returned 34 articles. These are shown in red on Figure 2. This is an indication that the health sciences community is becoming increasingly sensitized to the issue of pragmatism. It is important to keep in mind that the majority of these studies were conducted in primary care settings.